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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1989-12-29
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pubmed:abstractText |
Amplification of the N-myc oncogene in human neuroblastoma is associated with increased metastatic ability. We previously found that over-expression of N-myc in rat neuroblastoma tumor cells causes a dramatic reduction in the expression of MHC class I mRNA. We show here that two distinct elements in the promoter render the MHC class I genes susceptible to N-myc-mediated suppression, one of which was identified as the MHC class I gene enhancer. Our data indicate that elevated N-myc expression is associated with reduced binding of a transcription factor that activates this enhancer. As a result, the activity of the MHC class I gene enhancer is greatly diminished. Elevated expression of the N-myc oncogene in human neuroblastomas and murine pre-B lymphoid lines also correlated with reduced factor binding to the MHC class I gene enhancer. Thus, an important effect of N-myc may be to impair the function of certain cellular enhancers by altering the levels of their cognate binding proteins.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-2419762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-2484015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-2493990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-2839774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-291030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-2944600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-2951590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-2964277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-2968500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-2968712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-2982503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-2999984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3025651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3037497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3096575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3109035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3129195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3130660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3135940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3322806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3402430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3422454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3510743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3555845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3561391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3796607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-3823900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-6090941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-6095113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-6246378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-6302193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-6355856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-6828386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-6960240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583102-7151177
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3351-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2583102-Animals,
pubmed-meshheading:2583102-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:2583102-Enhancer Elements, Genetic,
pubmed-meshheading:2583102-Gene Expression,
pubmed-meshheading:2583102-Genes, MHC Class I,
pubmed-meshheading:2583102-Humans,
pubmed-meshheading:2583102-Mutation,
pubmed-meshheading:2583102-Neuroblastoma,
pubmed-meshheading:2583102-Oncogenes,
pubmed-meshheading:2583102-Promoter Regions, Genetic,
pubmed-meshheading:2583102-Suppression, Genetic,
pubmed-meshheading:2583102-Transcription Factors,
pubmed-meshheading:2583102-Transfection,
pubmed-meshheading:2583102-Tumor Cells, Cultured
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pubmed:year |
1989
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pubmed:articleTitle |
Suppression of MHC class I gene expression by N-myc through enhancer inactivation.
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pubmed:affiliation |
Whitehead Institute for Biomedical Research, Cambridge MA 02142.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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