Linked Life Data

2573083

Source:http://linkedlifedata.com/resource/pubmed/id/2573083

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1224
pubmed:dateCreated
1989-11-27
pubmed:abstractText
Rapid advances in site-directed mutagenesis and total gene synthesis combined with new expression systems in prokaryotic and eukaryotic cells have provided the molecular biologist with tools for modification of existing proteins to improve catalytic activity, stability and selectivity, for construction of chimeric molecules and for synthesis of completely novel molecules that may be endowed with some useful activity. Such protein engineering can be seen as a cycle in which the structures of engineered molecules are studied by X-ray analysis and two-dimensional nuclear magnetic resonance. The results are used in the improvement of the design by using knowledge-based procedures that exploit facts, rules and observations about proteins of known three-dimensional structure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0962-8436
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
324
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
447-60
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Protein engineering and design.
pubmed:affiliation
Department of Crystallography, Birkbeck College, London, U.K.
pubmed:publicationType
Journal Article, Review