Source:http://linkedlifedata.com/resource/umls/id/C0033629
MSH: Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.,CSP: experimental or other man-made manipulations resulting in proteins which do not occur in nature; frequently, but not always, involves genetic manipulation.