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rdf:type |
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lifeskim:mentions |
umls-concept:C0005221,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0025936,
umls-concept:C0040300,
umls-concept:C0086222,
umls-concept:C0185117,
umls-concept:C1516960,
umls-concept:C1521840,
umls-concept:C1705733,
umls-concept:C2911684
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pubmed:issue |
10
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pubmed:dateCreated |
1989-12-29
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pubmed:abstractText |
To examine the role of human beta-globin enhancers in tissue-specific and developmental regulation, a hybrid beta-globin-simian virus 40 gene was analyzed in transgenic mice. A beta-globin DNA fragment containing two previously defined enhancers stimulated transcription from the simian virus 40 promoter in a tissue- and stage-specific pattern similar to that of the normal beta-globin gene. These results help to define the functions of beta-globin regulatory elements and suggest an approach for targeted expression of heterologous genes in erythroid cells in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-1157825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-2828176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-2828925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-2835225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-2911581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-2922063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-2924354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-2992937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-3039464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-3478680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-3690667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-3719696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-3858676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-3868484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-3982505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-6088069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-6091052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-6205764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-6291029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-6572107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-6578416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555696-6616614
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4581-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2555696-Aging,
pubmed-meshheading:2555696-Animals,
pubmed-meshheading:2555696-Embryonic and Fetal Development,
pubmed-meshheading:2555696-Enhancer Elements, Genetic,
pubmed-meshheading:2555696-Erythrocytes,
pubmed-meshheading:2555696-Globins,
pubmed-meshheading:2555696-Mice,
pubmed-meshheading:2555696-Mice, Transgenic,
pubmed-meshheading:2555696-Organ Specificity,
pubmed-meshheading:2555696-Promoter Regions, Genetic,
pubmed-meshheading:2555696-Recombinant Fusion Proteins,
pubmed-meshheading:2555696-Simian virus 40
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pubmed:year |
1989
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pubmed:articleTitle |
Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice.
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pubmed:affiliation |
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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