Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1989-12-21
|
| pubmed:abstractText |
The pattern of insulin-like growth factor II (IGF-II) mRNA expression in developing kidney and Wilms' tumor was examined with in situ hybridization. In developing kidney, IGF-II was primarily expressed in blastemal cells and lost with their differentiation. In triphasic Wilms' tumor, a similar relationship was found. But in a monomorphous Wilms', tumor cells with epithelial differentiation expressed IGF-II mRNA. These data suggest that IGF-II may be involved in fetal nephrogenesis, that its expression is inversely coupled to normal epithelial differentiation, and that this differentiation may be aberrantly regulated in Wilms' tumor.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0023-6837
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
61
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
522-6
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2554059-Child, Preschool,
pubmed-meshheading:2554059-Fetus,
pubmed-meshheading:2554059-Humans,
pubmed-meshheading:2554059-Insulin-Like Growth Factor II,
pubmed-meshheading:2554059-Kidney,
pubmed-meshheading:2554059-Nucleic Acid Hybridization,
pubmed-meshheading:2554059-RNA, Messenger,
pubmed-meshheading:2554059-Reference Values,
pubmed-meshheading:2554059-Somatomedins,
pubmed-meshheading:2554059-Wilms Tumor
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Expression of insulin-like growth factor-II mRNA in fetal kidney and Wilms' tumor. An in situ hybridization study.
|
| pubmed:affiliation |
Medicine Branch, National Cancer Institute, Bethesda, Maryland.
|
| pubmed:publicationType |
Journal Article
|