| pubmed-article:2552313 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2552313 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:2552313 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2552313 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:2552313 | lifeskim:mentions | umls-concept:C0024314 | lld:lifeskim |
| pubmed-article:2552313 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2552313 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2552313 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2552313 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2552313 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:2552313 | pubmed:dateCreated | 1989-11-7 | lld:pubmed |
| pubmed-article:2552313 | pubmed:abstractText | Epstein-Barr virus (EBV) has been associated with serious or fatal lymphoproliferative disease in immunocompromised patients. EBV nuclear protein 2 and latent membrane protein are characteristically expressed in B lymphocytes proliferating in vitro in response to growth transformation by EBV. These two proteins are thought to be effectors of lymphocyte growth since they increase the expression of B-lymphocyte activation (CD23) and cell-adhesion (LFA 3 and ICAM 1) molecules in vitro. Using monoclonal antibody-immune microscopy, we have demonstrated that these two EBV proteins and their associated B-lymphocyte activation or adhesion molecules are expressed in the infiltrating B lymphocytes in immunocompromised patients with EBV lymphoproliferative disease. These monoclonal antibodies should be useful in the early diagnosis of EBV lymphoproliferative disease and in distinguishing it from other B-lymphocyte cancers associated with EBV, such as Burkitt's lymphoma. The finding of EBV nuclear protein 2 and latent membrane protein and their associated activation or adhesion molecules provides a further pathophysiologic link between EBV and the proliferation of B lymphocytes in immunocompromised patients. | lld:pubmed |
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| pubmed-article:2552313 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2552313 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2552313 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2552313 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2552313 | pubmed:issn | 0028-4793 | lld:pubmed |
| pubmed-article:2552313 | pubmed:author | pubmed-author:YoungLL | lld:pubmed |
| pubmed-article:2552313 | pubmed:author | pubmed-author:EvansHH | lld:pubmed |
| pubmed-article:2552313 | pubmed:author | pubmed-author:ShapiroR SRS | lld:pubmed |
| pubmed-article:2552313 | pubmed:author | pubmed-author:RitzJJ | lld:pubmed |
| pubmed-article:2552313 | pubmed:author | pubmed-author:KieffEE | lld:pubmed |
| pubmed-article:2552313 | pubmed:author | pubmed-author:AndersonK CKC | lld:pubmed |
| pubmed-article:2552313 | pubmed:author | pubmed-author:O'HaraCC | lld:pubmed |
| pubmed-article:2552313 | pubmed:author | pubmed-author:RickinsonAA | lld:pubmed |
| pubmed-article:2552313 | pubmed:author | pubmed-author:HennessyKK | lld:pubmed |
| pubmed-article:2552313 | pubmed:author | pubmed-author:AlfieriCC | lld:pubmed |
| pubmed-article:2552313 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2552313 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:2552313 | pubmed:volume | 321 | lld:pubmed |
| pubmed-article:2552313 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2552313 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:2552313 | pubmed:pagination | 1080-5 | lld:pubmed |
| pubmed-article:2552313 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2552313 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2552313 | pubmed:articleTitle | Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. | lld:pubmed |
| pubmed-article:2552313 | pubmed:affiliation | Department of Cancer Studies, University of Birmingham, United Kingdom. | lld:pubmed |
| pubmed-article:2552313 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2552313 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2552313 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:2552313 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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