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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1989-11-7
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pubmed:abstractText |
Epstein-Barr virus (EBV) has been associated with serious or fatal lymphoproliferative disease in immunocompromised patients. EBV nuclear protein 2 and latent membrane protein are characteristically expressed in B lymphocytes proliferating in vitro in response to growth transformation by EBV. These two proteins are thought to be effectors of lymphocyte growth since they increase the expression of B-lymphocyte activation (CD23) and cell-adhesion (LFA 3 and ICAM 1) molecules in vitro. Using monoclonal antibody-immune microscopy, we have demonstrated that these two EBV proteins and their associated B-lymphocyte activation or adhesion molecules are expressed in the infiltrating B lymphocytes in immunocompromised patients with EBV lymphoproliferative disease. These monoclonal antibodies should be useful in the early diagnosis of EBV lymphoproliferative disease and in distinguishing it from other B-lymphocyte cancers associated with EBV, such as Burkitt's lymphoma. The finding of EBV nuclear protein 2 and latent membrane protein and their associated activation or adhesion molecules provides a further pathophysiologic link between EBV and the proliferation of B lymphocytes in immunocompromised patients.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/EBV-associated membrane antigen...,
http://linkedlifedata.com/resource/pubmed/chemical/Epstein-Barr Virus Nuclear Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fc,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0028-4793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
321
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
1080-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2552313-Adult,
pubmed-meshheading:2552313-Antibodies, Monoclonal,
pubmed-meshheading:2552313-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:2552313-Antigens, Viral,
pubmed-meshheading:2552313-B-Lymphocytes,
pubmed-meshheading:2552313-Cell Adhesion Molecules,
pubmed-meshheading:2552313-Diagnosis, Differential,
pubmed-meshheading:2552313-Epstein-Barr Virus Nuclear Antigens,
pubmed-meshheading:2552313-Female,
pubmed-meshheading:2552313-Herpesviridae Infections,
pubmed-meshheading:2552313-Herpesvirus 4, Human,
pubmed-meshheading:2552313-Humans,
pubmed-meshheading:2552313-Immune Tolerance,
pubmed-meshheading:2552313-Immunohistochemistry,
pubmed-meshheading:2552313-Lymph Nodes,
pubmed-meshheading:2552313-Lymphocyte Activation,
pubmed-meshheading:2552313-Lymphoproliferative Disorders,
pubmed-meshheading:2552313-Male,
pubmed-meshheading:2552313-Receptors, Fc,
pubmed-meshheading:2552313-Receptors, IgE,
pubmed-meshheading:2552313-Viral Matrix Proteins,
pubmed-meshheading:2552313-Viral Proteins
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pubmed:year |
1989
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pubmed:articleTitle |
Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease.
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pubmed:affiliation |
Department of Cancer Studies, University of Birmingham, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports,
Research Support, Non-U.S. Gov't
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