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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1989-5-24
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pubmed:abstractText |
The role of copper/zinc-containing superoxide dismutase (cSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) in metabolic defense against O2 toxicity in Drosophila is examined through the properties of a mutant strain carrying a cSOD-null mutation, cSODn108. Homozygotes are viable as larvae, which indicates that cSOD is not essential for cell viability per se. cSODn108 confers recessive sensitivity to the superoxide anion (O2-)-generator paraquat and to the transition metal compound CuSO4, which indicates that the cSOD-null condition in fact leads to impaired O2- metabolism. The primary biological consequences of the reduced O2- dismutation capacity of cSODn108 Drosophila are realized in the adult as infertility and reduction in life-span. We conclude that the infertility and reduced life-span of cSODn108 adults arise as a consequence of the reduced capacity of embryos, larvae, and pupae to adequately protect developing preimaginal cells from O2- -initiated cytotoxic damage.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-11933981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-213429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-225995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-2893664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-2981433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-3010861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-3011416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-3089213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-3128794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-3930429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-4751237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-4943714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-5389100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-6351251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-6592579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-6717088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-6782377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-6947277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2539600-7045874
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2761-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2539600-Animals,
pubmed-meshheading:2539600-Cations, Monovalent,
pubmed-meshheading:2539600-Copper,
pubmed-meshheading:2539600-Drosophila melanogaster,
pubmed-meshheading:2539600-Female,
pubmed-meshheading:2539600-Infertility, Female,
pubmed-meshheading:2539600-Infertility, Male,
pubmed-meshheading:2539600-Life Expectancy,
pubmed-meshheading:2539600-Male,
pubmed-meshheading:2539600-Paraquat,
pubmed-meshheading:2539600-Superoxide Dismutase,
pubmed-meshheading:2539600-Superoxides
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pubmed:year |
1989
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pubmed:articleTitle |
Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.
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pubmed:affiliation |
Department of Molecular Biology and Genetics, University of Guelph, ON, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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