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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1990-1-23
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pubmed:abstractText |
Circulating T cells from four patients with the hyper-IgE syndrome were found to produce significantly lower concentrations of interferon-gamma (IFN-gamma) in response to stimulation with phytohemagglutinin (PHA) than did T cells from eight age-matched healthy controls, three patients with atopic dermatitis and one patient with chronic granulomatous disease. A clonal analysis revealed that patients with hyper-IgE syndrome had markedly lower proportions of circulating T cells able to produce IFN-gamma and tumor necrosis factor-alpha (TNF-alpha) in comparison with controls. In contrast, the proportions of peripheral blood T cells able to produce IL-4 or IL-2 were not significantly different in patients and controls. All the four patients with hyper-IgE syndrome showed high proportions of circulating CD4+ helper T cells able to induce IgE synthesis in allogeneic B cells, as well. Such an activity for IgE synthesis appeared to be positively correlated with IL-4 production by T cells and inversely related to the ability of the same T cells to produce IFN-gamma. Since IFN-gamma exerts an inhibitory effect on the synthesis of IgE and both IFN-gamma and TNF-alpha play an important role in inflammatory reactions, we suggest that the defective production of IFN-gamma may be responsible for hyperproduction of IgE and the combined defect of IFN-gamma and TNF-alpha may contribute to the undue susceptibility to infections seen in patients with hyper-IgE syndrome.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-2643668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-2934482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-2967330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-2969394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-2969818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-3102244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-3102597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-3107127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-3109572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-360511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-5059313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-6185608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-6340757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-6392892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-6411853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-6417261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-6456275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-6600491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-6602150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-6816896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-7009746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531758-803218
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1830-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2531758-Adolescent,
pubmed-meshheading:2531758-Adult,
pubmed-meshheading:2531758-Child,
pubmed-meshheading:2531758-Female,
pubmed-meshheading:2531758-Humans,
pubmed-meshheading:2531758-Hypergammaglobulinemia,
pubmed-meshheading:2531758-Immunoglobulin E,
pubmed-meshheading:2531758-Interferon-gamma,
pubmed-meshheading:2531758-Leukocyte Count,
pubmed-meshheading:2531758-Phytohemagglutinins,
pubmed-meshheading:2531758-Syndrome,
pubmed-meshheading:2531758-T-Lymphocytes,
pubmed-meshheading:2531758-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:2531758-T-Lymphocytes, Regulatory,
pubmed-meshheading:2531758-Tumor Necrosis Factor-alpha
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pubmed:year |
1989
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pubmed:articleTitle |
Defective in vitro production of gamma-interferon and tumor necrosis factor-alpha by circulating T cells from patients with the hyper-immunoglobulin E syndrome.
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pubmed:affiliation |
Clinica Medica III, University of Florence, Policlinico Careggi, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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