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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1989-10-23
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pubmed:abstractText |
Interleukin-1 (IL-1) has been shown to have mitogenic and chemotactic properties for a variety of cell types includes keratinocytes. These studies suggested that keratinocytes possess receptors for IL-1. In this study, the chemotactic properties of IL-1 for keratinocytes were confirmed and IL-1 receptors were demonstrated on keratinocytes using a radio receptor assay. Crosslinking studies with IL-1 alpha identified two major bands of Mr 97 kDa and 133 kDa. Thus, keratinocytes possess high affinity IL-1 receptors and respond to IL-1 by directed migration.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0165-2478
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
22
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
123-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2528505-Cells, Cultured,
pubmed-meshheading:2528505-Chemotaxis,
pubmed-meshheading:2528505-Humans,
pubmed-meshheading:2528505-Interleukin-1,
pubmed-meshheading:2528505-Receptors, Immunologic,
pubmed-meshheading:2528505-Receptors, Interleukin-1,
pubmed-meshheading:2528505-Recombinant Proteins,
pubmed-meshheading:2528505-Skin
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pubmed:year |
1989
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pubmed:articleTitle |
Human interleukin-1 alpha is chemotactic for normal human keratinocytes.
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pubmed:affiliation |
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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