Linked Life Data

2525233

Source:http://linkedlifedata.com/resource/pubmed/id/2525233

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6225
pubmed:dateCreated
1989-7-18
pubmed:abstractText
The isolation and characterization of single gene mutations affecting the circadian biological clocks of several organisms has left little doubt that circadian rhythms can be subjected to classical genetical analysis. Many of these mutations occur at the same few genetic loci (frequency (frq) in the fungus Neurospora, and period (per) in fruit fly Drosophila); these loci represent the best studied clock-affecting genes known. Mutant strains are usually affected in more than one basic clock property, suggesting an inter-relatedness at the molecular level among these basic properties that would not have been predicted a priori. The extensive background information available concerning the frq locus provides a basis for the molecular dissection of the Neurospora circadian clock--the most minimal circadian system thus far described. We report here the cloning and analysis of the frq locus and show it to be larger and more complex than would have been predicted from the available genetic data. Complete rescue of all of the pleiotropic mutant phenotypes of the recessive frq allele requires transformation with a 7.7-kilobase (kb) region of DNA encoding at least two transcripts. Sequence analysis of this region has allowed the identification of a common element between frq and per which, given the background similarities in their classical genetic characteristics, suggests the possibility of a common element in the clock mechanisms of these two organisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
339
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
558-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
The Neurospora clock gene frequency shares a sequence element with the Drosophila clock gene period.
pubmed:affiliation
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03756.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't