| pubmed-article:2510930 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2510930 | lifeskim:mentions | umls-concept:C0220806 | lld:lifeskim |
| pubmed-article:2510930 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:2510930 | lifeskim:mentions | umls-concept:C0014609 | lld:lifeskim |
| pubmed-article:2510930 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:2510930 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:2510930 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:2510930 | lifeskim:mentions | umls-concept:C0040688 | lld:lifeskim |
| pubmed-article:2510930 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:2510930 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:2510930 | lifeskim:mentions | umls-concept:C1527195 | lld:lifeskim |
| pubmed-article:2510930 | lifeskim:mentions | umls-concept:C0162788 | lld:lifeskim |
| pubmed-article:2510930 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:2510930 | pubmed:dateCreated | 1989-12-27 | lld:pubmed |
| pubmed-article:2510930 | pubmed:abstractText | We have recently demonstrated the consistent detection of transforming growth factor alpha (TGF-alpha) in chemically transformed hamster oral tumors. By Northern blot analysis, no TGF-alpha mRNA can be detected in normal cheek pouch mucosa. The consistent expression of TGF-alpha associated with the malignant transformation in the well-defined hamster oral cancer model prompted us to hypothesize that the aberrant expression of this important cellular gene could be related to a specific stage of epithelial alteration. In situ hybridization was used to test this hypothesis. We now report that by in situ hybridization we can detect TGF-alpha mRNA in normal hamster oral epithelium and also at all stages of transformation. In all epithelium, labeling of TGF-alpha mRNA in the basal layer is more pronounced than that observed in the spinous and squamous layers. There is a significant increase of TGF-alpha mRNA labeling early in 7,12-dimethylbenz(a)anathracene-induced oral carcinogenesis. This increase is associated with morphological changes of epithelial hyperplasia or dysplasia. Although lesions exhibiting full-thickness epithelial dysplasia (carcinoma in situ) showed more labeling of TGF-alpha mRNA than do areas of lesser dysplasia, the transition to full-fledged papillary or invasive squamous cell carcinoma is not associated with further elevations of TGF-alpha expression. | lld:pubmed |
| pubmed-article:2510930 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2510930 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2510930 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2510930 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2510930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2510930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2510930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2510930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2510930 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2510930 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2510930 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:2510930 | pubmed:author | pubmed-author:WongD TDT | lld:pubmed |
| pubmed-article:2510930 | pubmed:author | pubmed-author:RayA KAK | lld:pubmed |
| pubmed-article:2510930 | pubmed:author | pubmed-author:ChangL CLC | lld:pubmed |
| pubmed-article:2510930 | pubmed:author | pubmed-author:ChoyRR | lld:pubmed |
| pubmed-article:2510930 | pubmed:author | pubmed-author:McBrideJJ | lld:pubmed |
| pubmed-article:2510930 | pubmed:author | pubmed-author:ChowM SMS | lld:pubmed |
| pubmed-article:2510930 | pubmed:author | pubmed-author:GallagherG... | lld:pubmed |
| pubmed-article:2510930 | pubmed:author | pubmed-author:MatossianKK | lld:pubmed |
| pubmed-article:2510930 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2510930 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2510930 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:2510930 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2510930 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2510930 | pubmed:pagination | 6700-7 | lld:pubmed |
| pubmed-article:2510930 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:meshHeading | pubmed-meshheading:2510930-... | lld:pubmed |
| pubmed-article:2510930 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2510930 | pubmed:articleTitle | Detection of transforming growth factor-alpha messenger RNA in normal and chemically transformed hamster oral epithelium by in situ hybridization. | lld:pubmed |
| pubmed-article:2510930 | pubmed:affiliation | Department of Oral Medicine and Oral Pathology, Harvard School of Dental Medicine, Boston, Massachusetts 02115. | lld:pubmed |
| pubmed-article:2510930 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2510930 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2510930 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2510930 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2510930 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2510930 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2510930 | lld:pubmed |
