| pubmed-article:2507923 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2507923 | lifeskim:mentions | umls-concept:C0022821 | lld:lifeskim |
| pubmed-article:2507923 | lifeskim:mentions | umls-concept:C0061928 | lld:lifeskim |
| pubmed-article:2507923 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2507923 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:2507923 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:2507923 | pubmed:issue | 6240 | lld:pubmed |
| pubmed-article:2507923 | pubmed:dateCreated | 1989-11-1 | lld:pubmed |
| pubmed-article:2507923 | pubmed:abstractText | The segmentation of the Drosophila body plan depends on a hierarchy of interactions among approximately 20-25 regulatory genes that are active in the early embryo (refs 1-4; for a review see ref. 5). The gap genes have a key role in this process and are responsible for the periodic expression of certain pair-rule genes and the localized expression of several homoeotic genes. The two best characterized gap genes, hunchback (hb) and Krüppel (Kr), contain homologies with the zinc-finger DNA-binding motif, although their mode of action in the early embryo is unknown. Here we report that both of the proteins encoded by these genes possess sequence-specific DNA-binding activities, which indicates that they might regulate gene expression at the level of transcription. The binding sites of the hb gene product are related by a 10-base pair (bp) consensus sequence, G/A C/C ATAAAAAA, whereas the binding sites of the Kr gene product share a distinct 10-bp motif, AACGGGTTAA. It is possible that the hb and Kr proteins cooperatively regulate gene expression, because they are expressed in broad, overlapping gradients in the early embryo. We also provide evidence that the on/off periodicity of the pair-rule gene even-skipped (eve) involves the interaction of the hb and Kr proteins with defined eve promoter elements. | lld:pubmed |
| pubmed-article:2507923 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2507923 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2507923 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2507923 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2507923 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2507923 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2507923 | pubmed:author | pubmed-author:LevineMM | lld:pubmed |
| pubmed-article:2507923 | pubmed:author | pubmed-author:Stanojevi?DD | lld:pubmed |
| pubmed-article:2507923 | pubmed:author | pubmed-author:HoeyTT | lld:pubmed |
| pubmed-article:2507923 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2507923 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:2507923 | pubmed:volume | 341 | lld:pubmed |
| pubmed-article:2507923 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2507923 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2507923 | pubmed:pagination | 331-5 | lld:pubmed |
| pubmed-article:2507923 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:2507923 | pubmed:meshHeading | pubmed-meshheading:2507923-... | lld:pubmed |
| pubmed-article:2507923 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2507923 | pubmed:articleTitle | Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila. | lld:pubmed |
| pubmed-article:2507923 | pubmed:affiliation | Department of Biological Sciences, Fairchild Center, Columbia University, New York, New York 10027. | lld:pubmed |
| pubmed-article:2507923 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2507923 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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