rdf:type |
|
lifeskim:mentions |
umls-concept:C0005456,
umls-concept:C0013138,
umls-concept:C0013935,
umls-concept:C0017262,
umls-concept:C0680730,
umls-concept:C1148554,
umls-concept:C1428114,
umls-concept:C1510827,
umls-concept:C1514562,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
|
pubmed:issue |
6232
|
pubmed:dateCreated |
1989-9-6
|
pubmed:abstractText |
The maternal gene bicoid is a key component of the system that determines the pattern of the anterior half of Drosophila embryos. The bicoid protein forms a concentration gradient in early embryos, and is known to bind DNA. Specific binding sites are now shown to confer expression in a region of the embryo that depends on their affinity for bicoid protein: sites of high affinity allow expression further down the bicoid protein gradient than sites of low affinity.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0028-0836
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
3
|
pubmed:volume |
340
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
363-7
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:2502714-Animals,
pubmed-meshheading:2502714-Binding Sites,
pubmed-meshheading:2502714-DNA,
pubmed-meshheading:2502714-Drosophila,
pubmed-meshheading:2502714-Gene Expression Regulation,
pubmed-meshheading:2502714-Heat-Shock Proteins,
pubmed-meshheading:2502714-Homeodomain Proteins,
pubmed-meshheading:2502714-Insect Hormones,
pubmed-meshheading:2502714-Promoter Regions, Genetic,
pubmed-meshheading:2502714-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:2502714-Trans-Activators,
pubmed-meshheading:2502714-Zygote,
pubmed-meshheading:2502714-beta-Galactosidase
|
pubmed:year |
1989
|
pubmed:articleTitle |
Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen.
|
pubmed:affiliation |
Max-Planck-Institut für Entwicklungsbiologie, Abteilung Genetik, Tübingen, FRG.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|