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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-7-14
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pubmed:abstractText |
Starfish oocytes injected with pertussis toxin (3-6 micrograms/ml) or its catalytically active A-subunit (1 microgram/ml) did not undergo germinal vesicle breakdown in response to 1-methyladenine (1-10 microM). The pertussis block could be bypassed by transfer of cytoplasm that contained maturation-promoting factor (MPF). After insemination, pertussis-blocked, MPF-rescued oocytes underwent cortical vesicle exocytosis and cleavage. These results suggest the involvement of a pertussis sensitive G-protein in the pathway coupling 1-methyladenine action at the cell surface to the reinitiation of meiosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0012-1606
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
605-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2499496-Adenine,
pubmed-meshheading:2499496-Animals,
pubmed-meshheading:2499496-Cytoplasm,
pubmed-meshheading:2499496-Exocytosis,
pubmed-meshheading:2499496-Female,
pubmed-meshheading:2499496-GTP-Binding Proteins,
pubmed-meshheading:2499496-Growth Substances,
pubmed-meshheading:2499496-Maturation-Promoting Factor,
pubmed-meshheading:2499496-Oocytes,
pubmed-meshheading:2499496-Pertussis Toxin,
pubmed-meshheading:2499496-Starfish,
pubmed-meshheading:2499496-Virulence Factors, Bordetella
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pubmed:year |
1989
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pubmed:articleTitle |
Pertussis toxin inhibits 1-methyladenine-induced maturation in starfish oocytes.
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pubmed:affiliation |
Department of Biology, University of Southern California, Los Angeles 90089.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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