Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-5-19
pubmed:abstractText
Immunoglobulin gene-specific transacting factors have been shown to play a role in lymphoid tissue-specific expression of immunoglobulin genes. The role of these factors in B-cell differentiation and stage-specific expression of these genes is, however, not fully understood. We have used a model of human lymphoid neoplasia to address this question. Different fragments of unrearranged human variable region of immunoglobulin kappa gene (V kappa) were used for cell-free in vitro transcription and DNA mobility shift assays. Previously described enhancement of in vitro transcription that was only seen with nuclear extracts derived from B-cell neoplasms corresponding to the late stages of B-cell differentiation was shown to be dependent on the actions of these factor(s) on the DNA region within the V kappa gene promoter. This region is located within the 920 bp fragment located 210 bp upstream from the coding region and this fragment represents a possible novel DNA region, which plays a role in the stage- and tissue-specific expression of immunoglobulin genes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-2414668, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-2836666, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-2994213, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-2998773, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3019664, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3037335, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3079910, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3088544, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3091258, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3092107, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3093895, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3095662, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3095838, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3096580, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3098435, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3122182, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3132611, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3495468, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3537963, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3627254, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3786139, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3917574, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3917575, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6091050, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6206193, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6210879, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6265099, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6305160, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6319016, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6751039, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6828386, http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6933441
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
328-34
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Novel region within the V kappa gene promoter is responsible for tissue and stage-specific expression of immunoglobulin genes in human lymphoid neoplasms.
pubmed:affiliation
Department of Pathology, University of Calgary/Foothills Hospital, Alberta, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't