rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0017350,
umls-concept:C0040300,
umls-concept:C0086418,
umls-concept:C0086860,
umls-concept:C0185117,
umls-concept:C0205147,
umls-concept:C0205314,
umls-concept:C0598798,
umls-concept:C0679622,
umls-concept:C1273518,
umls-concept:C2911684
|
pubmed:issue |
3
|
pubmed:dateCreated |
1989-5-19
|
pubmed:abstractText |
Immunoglobulin gene-specific transacting factors have been shown to play a role in lymphoid tissue-specific expression of immunoglobulin genes. The role of these factors in B-cell differentiation and stage-specific expression of these genes is, however, not fully understood. We have used a model of human lymphoid neoplasia to address this question. Different fragments of unrearranged human variable region of immunoglobulin kappa gene (V kappa) were used for cell-free in vitro transcription and DNA mobility shift assays. Previously described enhancement of in vitro transcription that was only seen with nuclear extracts derived from B-cell neoplasms corresponding to the late stages of B-cell differentiation was shown to be dependent on the actions of these factor(s) on the DNA region within the V kappa gene promoter. This region is located within the 920 bp fragment located 210 bp upstream from the coding region and this fragment represents a possible novel DNA region, which plays a role in the stage- and tissue-specific expression of immunoglobulin genes.
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-2414668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-2836666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-2994213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-2998773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3019664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3037335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3079910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3088544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3091258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3092107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3093895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3095662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3095838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3096580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3098435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3122182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3132611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3495468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3537963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3627254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3786139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3917574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-3917575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6091050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6206193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6210879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6265099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6305160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6319016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6751039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6828386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495246-6933441
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0019-2805
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
66
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
328-34
|
pubmed:dateRevised |
2009-11-18
|
pubmed:meshHeading |
pubmed-meshheading:2495246-B-Lymphocytes,
pubmed-meshheading:2495246-Cell Line,
pubmed-meshheading:2495246-Humans,
pubmed-meshheading:2495246-Immunoglobulin Variable Region,
pubmed-meshheading:2495246-Immunoglobulin kappa-Chains,
pubmed-meshheading:2495246-Lymphoma,
pubmed-meshheading:2495246-Neoplasm Staging,
pubmed-meshheading:2495246-Nuclear Proteins,
pubmed-meshheading:2495246-Promoter Regions, Genetic,
pubmed-meshheading:2495246-Transcription, Genetic,
pubmed-meshheading:2495246-Transcription Factors
|
pubmed:year |
1989
|
pubmed:articleTitle |
Novel region within the V kappa gene promoter is responsible for tissue and stage-specific expression of immunoglobulin genes in human lymphoid neoplasms.
|
pubmed:affiliation |
Department of Pathology, University of Calgary/Foothills Hospital, Alberta, Canada.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|