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pubmed-article:2494667pubmed:abstractTextWe have isolated genomic and cDNA clones for a Drosophila gene resembling the human beta-amyloid precursor protein (APP). This gene produces a nervous system-enriched 6.5-kilobase transcript. Sequencing of cDNAs derived from the 6.5-kilobase transcript predicts an 886-amino acid polypeptide. This polypeptide contains a putative transmembrane domain and exhibits strong sequence similarity to cytoplasmic and extracellular regions of the human beta-amyloid precursor protein. There is a high probability that this Drosophila gene corresponds to the essential Drosophila locus vnd, a gene required for embryonic nervous system development.lld:pubmed
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pubmed-article:2494667pubmed:articleTitleA Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor.lld:pubmed
pubmed-article:2494667pubmed:affiliationDepartment of Biology, Brandeis University, Waltham, MA 02254.lld:pubmed
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