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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1989-5-5
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pubmed:databankReference |
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pubmed:abstractText |
We have isolated genomic and cDNA clones for a Drosophila gene resembling the human beta-amyloid precursor protein (APP). This gene produces a nervous system-enriched 6.5-kilobase transcript. Sequencing of cDNAs derived from the 6.5-kilobase transcript predicts an 886-amino acid polypeptide. This polypeptide contains a putative transmembrane domain and exhibits strong sequence similarity to cytoplasmic and extracellular regions of the human beta-amyloid precursor protein. There is a high probability that this Drosophila gene corresponds to the essential Drosophila locus vnd, a gene required for embryonic nervous system development.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-116132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-16453459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-17248807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-2881207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-2893289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-2893290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-2893291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-2900137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-2900758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-2949367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-2968652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-3023069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-3035574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-3107982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-3112354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-3131880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-3299701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-3810169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-3822832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-3926976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-4065091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-5420325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-6329730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-6375662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-6411520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-6777047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-6778748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494667-7108955
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2478-82
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:2494667-Amino Acid Sequence,
pubmed-meshheading:2494667-Amyloid,
pubmed-meshheading:2494667-Amyloid beta-Protein Precursor,
pubmed-meshheading:2494667-Animals,
pubmed-meshheading:2494667-Base Sequence,
pubmed-meshheading:2494667-Blotting, Northern,
pubmed-meshheading:2494667-Chromosome Mapping,
pubmed-meshheading:2494667-Cloning, Molecular,
pubmed-meshheading:2494667-Drosophila melanogaster,
pubmed-meshheading:2494667-Genes,
pubmed-meshheading:2494667-Humans,
pubmed-meshheading:2494667-Membrane Proteins,
pubmed-meshheading:2494667-Molecular Sequence Data,
pubmed-meshheading:2494667-Protein Precursors,
pubmed-meshheading:2494667-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2494667-Transcription, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor.
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pubmed:affiliation |
Department of Biology, Brandeis University, Waltham, MA 02254.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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