Linked Life Data

2477929

Source:http://linkedlifedata.com/resource/pubmed/id/2477929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-11-2
pubmed:abstractText
The purpose of this study was to determine if ultrasound radiation would affect the ability of antigen-stimulated B cells and their clonal progeny to undergo the isotype switch and produce diverse antibody classes. Pregnant BALB/c mice were exposed to various intensities of ultrasound (0.1-3.0 W/cm2) at different ages of gestation. Spleens from the resulting offspring were removed five or ten days after birth. The splenocytes were analyzed for the frequency of B cells capable of responding to the hapten 2,4 dinitrophenyl (DNP) using the splenic fragment assay, a B cell cloning assay. The DNP-responsive B cell clones were then classified on the basis of isotype expression. It was found that ultrasonic radiation during gestation did not alter the frequency of B cells responding to DNP. Furthermore, ultrasound had no apparent effect on the B lymphocyte's capacity to switch to different isotypes after antigenic stimulation. Thus, the results indicate that prenatal exposure to ultrasound does not appreciably affect the genetic and cellular processes necessary for the isotype switch and antibody class production.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-5629
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
581-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effect of fetal exposure to ultrasound on B lymphocyte function and antibody class production.
pubmed:affiliation
Department of Microbiology, University of Texas Health Science Center, San Antonio 78284.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't