Linked Life Data

2472478

Source:http://linkedlifedata.com/resource/pubmed/id/2472478

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-8-10
pubmed:abstractText
Administration of estradiol benzoate to ovariectomized rats results in an increased binding of [3H]muscimol, [3H]diazepam and 35S-t-butylbicyclophosphorothionate in various areas of the central nervous system of rats. The effect is dose-dependent and its onset can be observed as early as 12 hr after s.c. administration of the hormone. The various binding activities are differentially affected by the hormonal treatment: the maximal effect observed for [3H]diazepam binding is in the cerebellum (+42%), for [3H]muscimol binding in the frontal cortex (+84%) and for 35S-t-butylbicyclophosphorothionate binding in the striatum (+46%) indicating that the activities of the sites are not under the same cellular regulatory control. The estrogen-induced increase in [3H]diazepam binding sites does not result in an increased protection against chemoconvulsants such as pentylenetetrazole.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
244
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1005-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Estrogen modulation of the gamma-aminobutyric acid receptor complex in the central nervous system of rat.
pubmed:affiliation
Milano Molecular Pharmacology Lab, University of Milan, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't