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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1989-6-7
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pubmed:abstractText |
The role of exonuclease III and endonuclease IV in the repair of pyrimidine dimers in bacteriophage T4-infected Escherichia coli was examined. UV-irradiated T4 showed reduced survival when plated on an xth nfo double mutant but showed wild-type survival on either single mutant. T4 denV phage were equally sensitive when plated on wild-type E. coli or an xth nfo double mutant, suggesting that these endonucleases function in the same repair pathway as T4 pyrimidine dimer-DNA glycosylase. A uvrA mutant of E. coli in which the repair of pyrimidine dimers was dependent on the T4 denV gene carried on a plasmid was constructed. Neither an xth nor an nfo derivative of this strain was more sensitive than the parental strain to UV irradiation. We were unable to construct a uvrA xth nfo triple mutant. In addition, T4, which turns off the host UvrABC excision nuclease, showed reduced plating efficiency on an xth nfo double mutant.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-13952844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-14159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-17247760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-2430946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-2439070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-2442140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-2457010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-2457392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-2460435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-2582408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-2959841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-3049539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-3052275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-3327518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-3886628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-4559796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-4566437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-4567285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-4568763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-4924206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-5335128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-6250044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-6253795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-6254032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-6254991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-6273443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-6277906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-6277916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-6282808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-6294597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-6753948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468648-780339
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apurinic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Glycosylases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-(Apurinic or Apyrimidinic...,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonuclease IV (Phage...,
http://linkedlifedata.com/resource/pubmed/chemical/Endodeoxyribonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Exodeoxyribonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/N-Glycosyl Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Polynucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidine Dimers,
http://linkedlifedata.com/resource/pubmed/chemical/deoxyribopyrimidine endonucleosidase,
http://linkedlifedata.com/resource/pubmed/chemical/endonuclease IV, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/exodeoxyribonuclease III
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2542-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2468648-Apurinic Acid,
pubmed-meshheading:2468648-DNA Glycosylases,
pubmed-meshheading:2468648-DNA Repair,
pubmed-meshheading:2468648-DNA-(Apurinic or Apyrimidinic Site) Lyase,
pubmed-meshheading:2468648-Deoxyribonuclease IV (Phage T4-Induced),
pubmed-meshheading:2468648-Endodeoxyribonucleases,
pubmed-meshheading:2468648-Escherichia coli,
pubmed-meshheading:2468648-Escherichia coli Proteins,
pubmed-meshheading:2468648-Exodeoxyribonucleases,
pubmed-meshheading:2468648-Mutation,
pubmed-meshheading:2468648-N-Glycosyl Hydrolases,
pubmed-meshheading:2468648-Polynucleotides,
pubmed-meshheading:2468648-Pyrimidine Dimers,
pubmed-meshheading:2468648-T-Phages,
pubmed-meshheading:2468648-Ultraviolet Rays,
pubmed-meshheading:2468648-Virus Replication
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pubmed:year |
1989
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pubmed:articleTitle |
Role of exonuclease III and endonuclease IV in repair of pyrimidine dimers initiated by bacteriophage T4 pyrimidine dimer-DNA glycosylase.
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pubmed:affiliation |
Department of Biological Sciences, State University of New York, Albany 12222.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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