Linked Life Data

2461886

Source:http://linkedlifedata.com/resource/pubmed/id/2461886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-1-13
pubmed:abstractText
We have isolated and initially characterized a novel set of four genes expressed during the prepupal differentiation of imaginal discs of Drosophila melanogaster. These four ecdysone-dependent genes are named EDG-42A, EDG-64CD, EDG-78E and EDG-84A-1 based on their respective chromosomal locations. Their expression is like that expected for genes encoding proteins that participate in the formation of the pupal cuticle. Transcripts complementary to these genes accumulate in imaginal discs during an 18-hr in vitro culture period that begins with a 6-hr pulse of 20-hydroxyecdysone (20-HE). Transcripts for three of these genes were not detected in imaginal discs following culture in the absence or the continuous presence of 20-HE (1 microgram/ml). Transcripts corresponding to EDG-64CD exhibit delayed accumulation in the continuous presence of 20-HE. Transcripts corresponding to three of the genes are only detected in the prepupal stage of development. Only EDG-64CD is complementary to transcripts present at other stages of development. One of the genes, EDG-78E, encodes a pupal cuticle protein. This is the first reported isolation of a set of steroid hormone-responsive genes that require first the presence, then removal of hormone for transcript accumulation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-110452, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-216009, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-3007512, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-3079769, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-322279, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-3891759, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-4207978, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-518835, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-6168386, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-6173274, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-6441593, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-6807731, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-7035466, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-719759, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-825404, http://linkedlifedata.com/resource/pubmed/commentcorrection/2461886-99471
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
465-74
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Prepupal differentiation of Drosophila imaginal discs: identification of four genes whose transcripts accumulate in response to a pulse of 20-hydroxyecdysone.
pubmed:affiliation
Department of Genetics, University of California, Berkeley 94720.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't