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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1988-4-19
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pubmed:databankReference |
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pubmed:abstractText |
Human insulin-like growth factor II (IGF-II) cDNA from a placental library was isolated and sequenced. The 5' untranslated region (5'-UTR) sequence of this cDNA differs completely from that of adult human liver and has considerable base sequence identity to the same region of an IGF-II cDNA of a rat liver cell line, BRL-3A. Human placental poly(A)+ RNA was probed with either the 5'-UTR of the isolated human placental IGF-II cDNA or the 5'-UTR of the IGF-II cDNA obtained from adult human liver. No transcripts were detected by using the 5'-UTR of the adult liver IGF-II as the probe. In contrast, three transcripts of 6.0, 3.2, and 2.2 kilobases were detected by using the 5'-UTR of the placental IGF-II cDNA as the probe or the probe from the coding sequence. A fourth IGF-II transcript of 4.9 kilobases presumably containing a 5'-UTR consisting of a base sequence dissimilar to that of either IGF-II 5'-UTR was apparent. Therefore, IGF-II transcripts detected may be products of alternative splicing as their 5'-UTR sequence is contained within the human IGF-II gene or they may be a consequence of alternative promoter utilization in placenta.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-2438416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-2991285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-2995817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-2995818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-3002851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-3023383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-3466182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-3476948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-3569524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-3652904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-3653397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-3881277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-3901002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6092382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6162570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6190572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6198242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6202445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6304143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-632300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6338399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6358902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6382021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6382022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6414718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-6432335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-658418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-7039847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-7356482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2450353-7372001
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1947-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2450353-Amino Acid Sequence,
pubmed-meshheading:2450353-Animals,
pubmed-meshheading:2450353-Base Sequence,
pubmed-meshheading:2450353-DNA,
pubmed-meshheading:2450353-Humans,
pubmed-meshheading:2450353-Insulin-Like Growth Factor II,
pubmed-meshheading:2450353-Liver,
pubmed-meshheading:2450353-Molecular Sequence Data,
pubmed-meshheading:2450353-Placenta,
pubmed-meshheading:2450353-Poly A,
pubmed-meshheading:2450353-Protein Biosynthesis,
pubmed-meshheading:2450353-RNA,
pubmed-meshheading:2450353-RNA, Messenger,
pubmed-meshheading:2450353-Rats,
pubmed-meshheading:2450353-Somatomedins
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pubmed:year |
1988
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pubmed:articleTitle |
Isolation of an insulin-like growth factor II cDNA with a unique 5' untranslated region from human placenta.
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pubmed:affiliation |
Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH 44106.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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