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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-2-9
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pubmed:abstractText |
IL-1 is a family of polypeptides which play a critical role in the inflammatory response. Characteristics of this response include an enhanced release of bone marrow neutrophils, activation of circulating and tissue-phase phagocytes, and enhanced production of neutrophils and monocytes. We have sought to understand the hematopoietic response to acute and chronic inflammatory states on a cellular and molecular level. Colony-stimulating factors (CSFs) are glycoproteins involved in the production and activation of neutrophils and monocytes in vitro and in vivo. We have found that quiescent dermal fibroblasts constitutively release granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), and macrophage CSF in culture, and that picomolar concentrations of the inflammatory mediator IL-1 stimulate by at least fivefold the transcription and release of GM-CSF and G-CSF. These findings establish the role of IL-1 in the hematopoietic response to inflammation through the stimulation of the production and release of GM-CSF and G-CSF.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-2420009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-2428865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-2871846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-2933048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-2989698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-2996129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3002522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3010124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3081887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3298430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3458209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3484491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3484685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3484805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3486413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3486886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3487734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3489530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3490494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3492227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3493529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3499177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3871966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3902871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-3970734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-4029289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-573889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-6232133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-6600462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-6600620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-6603879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-6690455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-6836306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-6972953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-7040421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2447127-881736
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
92-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2447127-Animals,
pubmed-meshheading:2447127-Colony-Forming Units Assay,
pubmed-meshheading:2447127-Colony-Stimulating Factors,
pubmed-meshheading:2447127-Culture Media,
pubmed-meshheading:2447127-Fibroblasts,
pubmed-meshheading:2447127-Granulocytes,
pubmed-meshheading:2447127-Humans,
pubmed-meshheading:2447127-Interleukin-1,
pubmed-meshheading:2447127-Macrophages,
pubmed-meshheading:2447127-Mice,
pubmed-meshheading:2447127-Mice, Inbred Strains,
pubmed-meshheading:2447127-RNA
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pubmed:year |
1988
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pubmed:articleTitle |
Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation.
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pubmed:affiliation |
Division of Hematology, University of Washington, Seattle 98195.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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