Linked Life Data

2439608

Source:http://linkedlifedata.com/resource/pubmed/id/2439608

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-7-28
pubmed:abstractText
Recent studies have suggested that T lymphocytes with helper phenotype may play an important role in the pathogenesis of lichenoid tissue reactions (LTR). In order to elucidate whether murine self-Ia-specific autoreactive T cells with helper phenotype can induce LTR in naive syngeneic hosts, two clones of autoreactive cloned T cells with both helper and cytotoxic activities, capable of producing the cytotoxic lymphokines gamma interferon and lymphotoxin in response to self-Ia antigens, were examined for their ability to induce LTR. One clone, BB5, when injected into footpads of syngeneic hosts, induced prominent epidermotropic cellular infiltrates that led to basal vacuolar degeneration and Civatte body formation; the other clone, C10, did not. No difference between BB5 and C10 was detected with respect to their ability to induce delayed-type hypersensitivity reactions. Immunohistochemical studies using anti-Lyt monoclonal antibodies showed that BB5-induced LTR was induced by the epidermal invasion of the injected BB5 cells themselves. We further observed that the infusion of BB5 cells not only resulted in Ia antigen expression on keratinocytes, but was also accompanied by a morphologic change in Langerhans cells at 24 h, when the epidermal invasion had not yet developed. However, similar observations were also observed with C10 cells, indicating that Ia expression on keratinocytes may not be a prerequisite for the induction of LTR.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8-14
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Lichenoid tissue reaction (LTR) induced by local transfer of Ia-reactive T-cell clones. II. LTR by epidermal invasion of cytotoxic lymphokine-producing autoreactive T cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't