pubmed-article:2435161 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2435161 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
pubmed-article:2435161 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
pubmed-article:2435161 | lifeskim:mentions | umls-concept:C0025148 | lld:lifeskim |
pubmed-article:2435161 | lifeskim:mentions | umls-concept:C0001629 | lld:lifeskim |
pubmed-article:2435161 | lifeskim:mentions | umls-concept:C0015385 | lld:lifeskim |
pubmed-article:2435161 | lifeskim:mentions | umls-concept:C1550278 | lld:lifeskim |
pubmed-article:2435161 | lifeskim:mentions | umls-concept:C0949653 | lld:lifeskim |
pubmed-article:2435161 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
pubmed-article:2435161 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
pubmed-article:2435161 | lifeskim:mentions | umls-concept:C0205385 | lld:lifeskim |
pubmed-article:2435161 | pubmed:issue | 2 Pt 1 | lld:pubmed |
pubmed-article:2435161 | pubmed:dateCreated | 1987-3-30 | lld:pubmed |
pubmed-article:2435161 | pubmed:abstractText | Ca2+-activated K+ channels with estimated single channel conductances of 127 +/- 2 pS were identified in the apical cell membrane of clone A3 of cultured medullary thick ascending limb (MTAL) cells. Both Ba2+ and the scorpion toxin, charybdotoxin (CTX), are slow blockers of the channels. An application of 0.1 microM Ba2+ to the intracellular face caused a 50% reduction in fractional open time (fv). Ba2+ block is both concentration and voltage dependent. Concentrations of CTX as low as 2 nM in the extracellular solution caused a significant reduction in fv. Tetraethylammonium (TEA) and quinine are fast blockers of Ca2+-activated K+ channels in MTAL cells. TEA, 400 microM, in the extracellular solution caused a voltage-dependent reduction in channel amplitude, whereas it takes 10 mM in the intracellular solution to reduce channel amplitude by 30%. Micromolar amounts of quinine applied to the intracellular face caused the channels to flicker rapidly between open and blocked states. These results suggest that K+ channels in MTAL cells are homologous to those found in muscle cells, and that these blocking agents may be used to probe the nature of K+ conductances in several nephron segments. | lld:pubmed |
pubmed-article:2435161 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2435161 | pubmed:language | eng | lld:pubmed |
pubmed-article:2435161 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2435161 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:2435161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2435161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2435161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:2435161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2435161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2435161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:2435161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2435161 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2435161 | pubmed:month | Feb | lld:pubmed |
pubmed-article:2435161 | pubmed:issn | 0002-9513 | lld:pubmed |
pubmed-article:2435161 | pubmed:author | pubmed-author:SacktorBB | lld:pubmed |
pubmed-article:2435161 | pubmed:author | pubmed-author:GreerJJ | lld:pubmed |
pubmed-article:2435161 | pubmed:author | pubmed-author:GugginoS ESE | lld:pubmed |
pubmed-article:2435161 | pubmed:author | pubmed-author:GugginoW BWB | lld:pubmed |
pubmed-article:2435161 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2435161 | pubmed:volume | 252 | lld:pubmed |
pubmed-article:2435161 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2435161 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2435161 | pubmed:pagination | C128-37 | lld:pubmed |
pubmed-article:2435161 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:2435161 | pubmed:meshHeading | pubmed-meshheading:2435161-... | lld:pubmed |
pubmed-article:2435161 | pubmed:year | 1987 | lld:pubmed |
pubmed-article:2435161 | pubmed:articleTitle | Blocking agents of Ca2+-activated K+ channels in cultured medullary thick ascending limb cells. | lld:pubmed |
pubmed-article:2435161 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:2435161 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:2435161 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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