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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-12-10
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pubmed:abstractText |
Basophil releasability was studied in 24 cord blood samples from normal-term deliveries. The histamine content in cord blood basophils was similar to that of adult blood basophils. The response to IgE-independent degranulating stimuli such as calcium ionophore A23187 and zymosan-activated human serum was overlapping with that of normal adults. Conversely, a reduced releasability was observed after challenge with anti-IgE, even after sensitization with an IgE-rich serum. The IgE-dependent degranulation seems to be hampered by the low concentrations of circulating and cell-bound IgE antibodies. The number of IgE molecules bound to the specific receptors in cord blood basophils is significantly lower than in adult blood basophils.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0020-5915
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
276-83
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2429932-Adult,
pubmed-meshheading:2429932-Basophils,
pubmed-meshheading:2429932-Calcimycin,
pubmed-meshheading:2429932-Fetal Blood,
pubmed-meshheading:2429932-Histamine,
pubmed-meshheading:2429932-Histamine Release,
pubmed-meshheading:2429932-Humans,
pubmed-meshheading:2429932-Hydrogen-Ion Concentration,
pubmed-meshheading:2429932-Immunoglobulin E,
pubmed-meshheading:2429932-Infant, Newborn,
pubmed-meshheading:2429932-Receptors, Fc,
pubmed-meshheading:2429932-Receptors, IgE,
pubmed-meshheading:2429932-Receptors, Immunologic
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pubmed:year |
1986
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pubmed:articleTitle |
Functional evaluation of the basophil/IgE system in the cord blood.
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pubmed:publicationType |
Journal Article,
Comparative Study
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