Linked Life Data

2422440

Source:http://linkedlifedata.com/resource/pubmed/id/2422440

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-6-18
pubmed:abstractText
Pancreatic polypeptide (PP), a mammalian islet cell peptide, is released after a meal. Exogenously administered PP in physiologic doses inhibits cholecystokinin and secretin-stimulated pancreatic secretion in vivo. Whether PP acts directly on exocrine pancreatic cells is unknown. We studied the effects of PP on dispersed acini prepared from rat pancreas. Amylase release was determined after 30-min incubations of pancreatic acini with octapeptide of cholecystokinin (OP-CCK), secretin, and PP. The response to OP-CCK was augmented by secretin. PP decreased optimal amylase release evoked by OP-CCK and OP-CCK plus secretin. These observations demonstrate that PP acts directly on pancreatic cells to reduce acinar cell amylase release evoked by potent secretagogues.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
310-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Pancreatic polypeptide inhibits amylase release by rat pancreatic acini.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.