Linked Life Data

2416926

Source:http://linkedlifedata.com/resource/pubmed/id/2416926

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-2-20
pubmed:abstractText
Young adult rats were immunized with either in vitro glucosylated or unmodified rat serum albumin (RSA) followed by induction of the diabetic state. At various times after streptozotocin administration, sera were evaluated for specific antibody response using the enzyme-linked immunosorbent assay while urine was monitored for the presence of albumin by radial immunodiffusion. The data indicate that glucosylated RSA is capable of eliciting the production of antibodies, but unmodified RSA is not. The specificity of the generated antibodies appears to be directed toward the glucitol-lysine residues of the modified albumin. Preimmunization of rats with glucosylated RSA followed by induction of diabetes causes a rapid decline in specific antibody titers and greatly enhances the rate of progression to albuminuria. These results demonstrate that in vitro and in vivo glucosylation of an endogenous protein provide products with identical antigenicity. They also suggest an animal model for the study of diabetic autoimmunity involving glucosylated endogenous proteins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0141-2760
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Accelerated onset of albuminuria in diabetic rats preimmunized with glucosylated rat serum albumin.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't