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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1990-6-5
|
| pubmed:abstractText |
Recombinant human tumor necrosis factor (TNF) depressed the activities of both lipoprotein lipase (LPL) and hormone sensitive lipase (HSL) in 3T3-L1 adipocytes, 3 to 24 h after its introduction to the cells. HSL gene expression, as measured by Northern blotting analysis with 32P-labeled cloned HSL-cDNA, was also suppressed. These results suggested that the reduction in HSL activity caused by TNF resulted from inhibited gene expression of the enzyme.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0021-924X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
107
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-2
|
| pubmed:dateRevised |
2007-12-19
|
| pubmed:meshHeading |
pubmed-meshheading:2332411-Adipose Tissue,
pubmed-meshheading:2332411-Animals,
pubmed-meshheading:2332411-Carboxylic Ester Hydrolases,
pubmed-meshheading:2332411-Cell Line,
pubmed-meshheading:2332411-Gene Expression,
pubmed-meshheading:2332411-Mice,
pubmed-meshheading:2332411-RNA, Messenger,
pubmed-meshheading:2332411-Sterol Esterase,
pubmed-meshheading:2332411-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Inhibitory effect of tumor necrosis factor on gene expression of hormone sensitive lipase in 3T3-L1 adipocytes.
|
| pubmed:affiliation |
Second Department of Medical Biochemistry, School of Medicine, Ehime University.
|
| pubmed:publicationType |
Journal Article
|