| pubmed-article:2285223 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2285223 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2285223 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:2285223 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:2285223 | lifeskim:mentions | umls-concept:C0221920 | lld:lifeskim |
| pubmed-article:2285223 | lifeskim:mentions | umls-concept:C0085983 | lld:lifeskim |
| pubmed-article:2285223 | lifeskim:mentions | umls-concept:C0040688 | lld:lifeskim |
| pubmed-article:2285223 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:2285223 | lifeskim:mentions | umls-concept:C1527195 | lld:lifeskim |
| pubmed-article:2285223 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2285223 | pubmed:dateCreated | 1991-3-15 | lld:pubmed |
| pubmed-article:2285223 | pubmed:abstractText | Pairs of cell lines from spontaneous human tumors (cervical adenocarcinoma, melanoma, and synovial sarcoma) were established using serum-free culture conditions with and without exogenous epidermal growth factor (EGF). EGF-adapted cultures of melanoma and cervical adenocarcinoma origin secreted higher levels of bioactive transforming growth factor alpha (TGF-alpha) when compared to cultures maintained in the absence of EGF. Depletion of EGF for these EGF-adapted cultures resulted in growth arrest. In contrast, the sarcoma cell lines did not secrete TGF-alpha regardless of the culture conditions but EGF significantly stimulated proliferation of these cells in short-term assays. We show that exogenous EGF induces TGF-alpha production and supports proliferation of tumor cells of various tissue origin but is not essential for in vitro growth factor-deprived conditions. | lld:pubmed |
| pubmed-article:2285223 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2285223 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2285223 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2285223 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2285223 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2285223 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2285223 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2285223 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2285223 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2285223 | pubmed:issn | 0250-7005 | lld:pubmed |
| pubmed-article:2285223 | pubmed:author | pubmed-author:HerlynMM | lld:pubmed |
| pubmed-article:2285223 | pubmed:author | pubmed-author:SpitzerGG | lld:pubmed |
| pubmed-article:2285223 | pubmed:author | pubmed-author:TuckerSS | lld:pubmed |
| pubmed-article:2285223 | pubmed:author | pubmed-author:RodeckUU | lld:pubmed |
| pubmed-article:2285223 | pubmed:author | pubmed-author:WilliamsN NNN | lld:pubmed |
| pubmed-article:2285223 | pubmed:author | pubmed-author:SingletaryS... | lld:pubmed |
| pubmed-article:2285223 | pubmed:author | pubmed-author:LarryLL | lld:pubmed |
| pubmed-article:2285223 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2285223 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:2285223 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2285223 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2285223 | pubmed:pagination | 1501-5 | lld:pubmed |
| pubmed-article:2285223 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:meshHeading | pubmed-meshheading:2285223-... | lld:pubmed |
| pubmed-article:2285223 | pubmed:articleTitle | Transforming growth factor-alpha secretion by epidermal growth factor-dependent human tumor cell lines. | lld:pubmed |
| pubmed-article:2285223 | pubmed:affiliation | Department of Surgery, University of Texas M. D. Anderson Cancer Center, Houston 77030. | lld:pubmed |
| pubmed-article:2285223 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2285223 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2285223 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
