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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0024320,
umls-concept:C0034493,
umls-concept:C0204514,
umls-concept:C0332256,
umls-concept:C0679058,
umls-concept:C0812246,
umls-concept:C1456820,
umls-concept:C1547699,
umls-concept:C1708726,
umls-concept:C2700640
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pubmed:issue |
2
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|
pubmed:dateCreated |
1991-1-16
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pubmed:databankReference |
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pubmed:abstractText |
The genes coding for 20-kDa lymphotoxin (TNF-beta) and tumor necrosis factor (TNF-alpha) have been cloned from a rabbit genomic library. The two genes are tandemly arranged and separated by only 1 kb of DNA, as previously observed in human and mouse genomes. We have sequenced the entire rabbit lymphotoxin-encoding gene and inferred the primary structure of rabbit TNF-beta, whose cDNA is not yet cloned. We also analysed the upstream sequences of the rabbit TNF-beta and TNF-alpha genes and identified a number of potential binding sites for known nuclear transcription factors, and in particular several putative kappa B-type sequences.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
95
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pubmed:geneSymbol |
TNF-&agr;,
TNF-&bgr;
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
215-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2249779-Amino Acid Sequence,
pubmed-meshheading:2249779-Animals,
pubmed-meshheading:2249779-Base Sequence,
pubmed-meshheading:2249779-Binding Sites,
pubmed-meshheading:2249779-Cloning, Molecular,
pubmed-meshheading:2249779-Consensus Sequence,
pubmed-meshheading:2249779-Gene Library,
pubmed-meshheading:2249779-Genes,
pubmed-meshheading:2249779-Humans,
pubmed-meshheading:2249779-Lymphotoxin-alpha,
pubmed-meshheading:2249779-Molecular Sequence Data,
pubmed-meshheading:2249779-Rabbits,
pubmed-meshheading:2249779-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:2249779-Restriction Mapping,
pubmed-meshheading:2249779-Sequence Alignment,
pubmed-meshheading:2249779-Transcription Factors,
pubmed-meshheading:2249779-Tumor Necrosis Factor-alpha
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pubmed:year |
1990
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pubmed:articleTitle |
Structural analysis of the rabbit TNF locus, containing the genes encoding TNF-beta (lymphotoxin) and TNF-alpha (tumor necrosis factor).
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pubmed:affiliation |
Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow.
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pubmed:publicationType |
Journal Article
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