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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1990-12-4
|
| pubmed:abstractText |
15 cases of HCL were studied with a panel of monoclonal antibodies against different leukocyte antigens. A B-cell phenotype different from that of B-CLL was observed (CD10-, CD19+, CD20+, CD21-, CD22+, CD37+, CD38-, FMC7+, LN1+, PCA-1+, BLy7+ and CD5-). As expected, CD11c and CD25 were positive and, in addition, a My7 and My9 positivity in varying degree was noted. 3 weeks of in vitro incubation did not significantly alter the phenotype. We conclude that HCL exhibits a unique phenotype among chronic B-cell leukemias, which is closer to the plasma cell stage of differentiation than that of B-CLL. The BLy7 monoclonal antibody seems to be a promising marker for HCL.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0902-4441
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
172-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2226730-Antigens, CD,
pubmed-meshheading:2226730-B-Lymphocytes,
pubmed-meshheading:2226730-Granulocytes,
pubmed-meshheading:2226730-Humans,
pubmed-meshheading:2226730-Immunophenotyping,
pubmed-meshheading:2226730-Leukemia, Hairy Cell,
pubmed-meshheading:2226730-Monocytes,
pubmed-meshheading:2226730-T-Lymphocytes
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Immunophenotype of hairy-cell leukemia.
|
| pubmed:affiliation |
Department of Pathology, University Hospital, Uppsala, Sweden.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|