Linked Life Data

2210719

Source:http://linkedlifedata.com/resource/pubmed/id/2210719

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-11-13
pubmed:abstractText
According to classical genetic theory, allelic genes at one locus are expected to segregate and be manifested independently of allelic genes at another locus. At the population level any significant deviation from this general hypothesis resulting from specific biologic and genetic effects can be recognized in the form of nonrandom associations between genetic markers. The present data, consisting of 24 genetic polymorphisms determined from a sample of 998 unselected and unrelated South African blacks, offers an opportunity to test whether or not any such nonrandom associations exist between the genetic markers. After appropriate statistical calculations on the population data, we found that 13 pairs of genetic polymorphisms demonstrate a nonrandom association (statistically significant). Because the results cannot be explained in terms of known biologic mechanisms, we conclude that the associations observed could be due to random statistical effects (repeated application of the chi-square test) and/or to real (as yet unknown) biologic phenomena in the population studied. This tentative conclusion can serve as a guideline for more specific investigations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0018-7143
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
525-34
pubmed:dateRevised
2011-4-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Nonrandom association of genetic markers in a sample of South African blacks.
pubmed:affiliation
Department of National Health and Population Development (Genetic Services), Pretoria, South Africa.
pubmed:publicationType
Journal Article