2208797

Source:http://linkedlifedata.com/resource/pubmed/id/2208797

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021390, umls-concept:C0032105, umls-concept:C0034819, umls-concept:C0040300, umls-concept:C0441889
pubmed:issue	1
pubmed:dateCreated	1990-11-13
pubmed:abstractText	Plasma and tissue interleukin-2 receptor (IL-2R) levels were determined in patients with active ulcerative colitis and Crohn's disease. Compared with healthy controls (median 440 U/ml; range 240-900), significantly higher levels of plasma IL-2R were present in patients with active ulcerative colitis (median 1180 U/ml; range 580-7150; P less than 0.002) and Crohn's disease (median 1340 U/ml; range 480-9000; P less than 0.002). Compared with other laboratory parameters, plasma IL-2R levels were related most closely to clinical score of disease activity in Crohn's disease. Plasma IL-2R levels also reflected the clinical course and may provide a more accurate assessment of disease activity in Crohn's disease. In plasma of patients undergoing intestinal resection of active inflammatory bowel disease, raised levels of IL-2R were present in samples from mesenteric vein (draining inflamed intestine) compared with those from peripheral vein. In tissue homogenates of colonic biopsies, significantly higher levels of IL-2R were present in specimens from colons with active ulcerative colitis compared with healthy controls (median 230.2, range 20.7-581.5 versus 77.9, range 34.2-291.3; P less than 0.02).
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-14075156, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-2565429, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-2567438, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-2568868, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-3040543, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-3108672, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-3266118, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-3266993, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-364626, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-3918914, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-3930598, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-6102236, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-6237813, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-6470178, http://linkedlifedata.com/resource/pubmed/commentcorrection/2208797-6607860
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0057202
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Prednisolone, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0009-9104
pubmed:author	pubmed-author:GallagherAA, pubmed-author:HawkeyC JCJ, pubmed-author:KurlakLL, pubmed-author:MahidaY RYR
pubmed:issnType	Print
pubmed:volume	82
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	75-80
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:2208797-Biopsy, pubmed-meshheading:2208797-Colitis, Ulcerative, pubmed-meshheading:2208797-Colon, pubmed-meshheading:2208797-Crohn Disease, pubmed-meshheading:2208797-Humans, pubmed-meshheading:2208797-Prednisolone, pubmed-meshheading:2208797-Receptors, Interleukin-2
pubmed:year	1990
pubmed:articleTitle	Plasma and tissue interleukin-2 receptor levels in inflammatory bowel disease.
pubmed:affiliation	Department of Therapeutics, University Hospital, Queen's Medical Centre, Nottingham, England, UK.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't