Linked Life Data

21851006

Source:http://linkedlifedata.com/resource/pubmed/id/21851006

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-8-19
pubmed:abstractText
The paper gives the results of a study of the levels of glycosaminoglycans (GAG) and hydroxyproline (HOP) in 87 apparently healthy individuals of both sexes, aged 19 to 60 years. There is a decrease in the levels of GAG, total HOP, and peptide-bound HOP with advanced age. These indices are higher in subjects less than 45 years old than in those over the age. The found age differences are comparable with higher serum hyaluronidase and collagenolytic activities in subjects younger than 45 years than in those over the age 45 years. Collagen metabolism occurs more intensively in young subjects (under 45 years of age) than in old ones (over 45). There are also gender-related differences: the men had higher levels of GAG and peptide-bound HOP and serum hyaluronidase activity than the women, which suggests that the metabolic rates of collagen and proteoglycans are higher. This difference is complimented by the qualitative characteristics of the process: there is a preponderance of the synthesis of collagen over its degradation with the accelerated degradation of proteoglycans in the young men. In Rh-positive subjects, the content of GAG was 22-fold higher than that in Rh-negative ones.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0869-2084
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-5
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
[The serum levels of glycosaminoglycans and hydroxyproline in relation to the age, gender, and blood group of apparently healthy individuals].
pubmed:publicationType
Journal Article, English Abstract