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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-8-4
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pubmed:abstractText |
Donor organ shortage represents a major problem in lung transplantation. Donation after cardiac death could help to expand the pool of organs, but the additional period of warm ischemia after cardiac arrest aggravates primary graft dysfunction. The pulmonary endothelium of the graft constitutes an important source and target of reactive oxygen species generated during ischemia and reperfusion. Targeted protection of graft pulmonary endothelial cells by the antioxidant enzyme catalase, conjugated with a platelet/endothelial cell adhesion molecule-1 (PECAM-1) antibody to nanosized particles (anti-PECAM/catalase conjugates), might improve outcome in lung transplantation using donors after cardiac death and prolonged hypothermic preservation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1534-6080
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pubmed:author |
pubmed-author:AlbeldaSteven MSM,
pubmed-author:BittmannIrisI,
pubmed-author:EbersbergerUlrichU,
pubmed-author:EichhornMartin EME,
pubmed-author:FischerKarlK,
pubmed-author:HermannsIrisI,
pubmed-author:HuffInes VIV,
pubmed-author:JauchKarl WKW,
pubmed-author:KirkpatrickJames CJC,
pubmed-author:LoeheFlorianF,
pubmed-author:MuzykantovVladimir RVR,
pubmed-author:PreisslerGerhardG,
pubmed-author:ShuvaevVladimir VVV,
pubmed-author:WiewrodtRainerR,
pubmed-author:WinterHaukeH
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
380-7
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pubmed:meshHeading |
pubmed-meshheading:21778930-Animals,
pubmed-meshheading:21778930-Antibodies,
pubmed-meshheading:21778930-Antigens, CD31,
pubmed-meshheading:21778930-Catalase,
pubmed-meshheading:21778930-Death,
pubmed-meshheading:21778930-Drug Delivery Systems,
pubmed-meshheading:21778930-Endothelial Cells,
pubmed-meshheading:21778930-Humans,
pubmed-meshheading:21778930-Immunoconjugates,
pubmed-meshheading:21778930-Lung Transplantation,
pubmed-meshheading:21778930-Nanoparticles,
pubmed-meshheading:21778930-Organ Preservation,
pubmed-meshheading:21778930-Oxidative Stress,
pubmed-meshheading:21778930-Pulmonary Gas Exchange,
pubmed-meshheading:21778930-Sus scrofa,
pubmed-meshheading:21778930-Tissue Donors
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pubmed:year |
2011
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pubmed:articleTitle |
Targeted endothelial delivery of nanosized catalase immunoconjugates protects lung grafts donated after cardiac death.
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pubmed:affiliation |
Department of Surgery, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Germany. Gerhard.Preissler@med.uni-muenchen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies,
Research Support, N.I.H., Extramural
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