Source:http://linkedlifedata.com/resource/pubmed/id/21725766
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2011-7-4
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| pubmed:abstractText |
Surgically induced brain injury (SBI) is a common concern after a neurosurgical procedure. Current treatments aimed at reducing the postoperative sequela are limited. Granulocyte-colony stimulating factor (G-CSF), a hematopoietic growth factor involved in the inflammatory process, has been shown in various animal models to be neuroprotective. Consequently, in this study, we investigated the use of G-CSF as a treatment modality to reduce cell death and brain edema, while improving neurobehavioral deficits following an SBI in mice. Eleven-week-old C57 black mice (n=76) were randomly placed into four groups: sham (n=19), SBI (n=21), SBI with G-CSF pre-treatment (n=15) and SBI with G-CSF pre/post-treatment (n=21). Treated groups received a single dose of G-CSF intraperitoneally at 24, 12 and 1 h pre-surgery and/or 6 and 12 h post-surgery. Postoperative assessment occurred at 24 h and included neurobehavioral testing and measurement for both cell death and brain edema. Results indicated that pre-treatment with G-CSF reduced both cell death and brain edema, while post-treatment reduced neurobehavioral deficits. This study implies that the morphological changes in the brain are effected by pre-treatment; however, in order to activate and/or amplify targets involved in the recovery process, more dosing regimens may be needed.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0065-1419
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
111
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
265-9
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| pubmed:meshHeading |
pubmed-meshheading:21725766-Animals,
pubmed-meshheading:21725766-Brain Edema,
pubmed-meshheading:21725766-Brain Injuries,
pubmed-meshheading:21725766-Cell Death,
pubmed-meshheading:21725766-Disease Models, Animal,
pubmed-meshheading:21725766-Dose-Response Relationship, Drug,
pubmed-meshheading:21725766-Drug Administration Schedule,
pubmed-meshheading:21725766-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21725766-Exploratory Behavior,
pubmed-meshheading:21725766-Functional Laterality,
pubmed-meshheading:21725766-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:21725766-Mice,
pubmed-meshheading:21725766-Movement,
pubmed-meshheading:21725766-Nervous System Diseases,
pubmed-meshheading:21725766-Neuroprotective Agents,
pubmed-meshheading:21725766-Neurosurgical Procedures,
pubmed-meshheading:21725766-Psychomotor Performance,
pubmed-meshheading:21725766-Time Factors,
pubmed-meshheading:21725766-Treatment Outcome,
pubmed-meshheading:21725766-Vibrissae
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| pubmed:year |
2011
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| pubmed:articleTitle |
Granulocyte colony-stimulating factor treatment provides neuroprotection in surgically induced brain injured mice.
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| pubmed:affiliation |
Department of Anesthesiology, Loma Linda Medical Center, Loma Linda, CA 92354, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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