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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2011-7-1
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pubmed:abstractText |
A series of inhibitors of mammalian 15-lipoxygenase (15-LO) based on a 3,4,5-tri-substituted pyrazole scaffold is described. Replacement of a sulfonamide functionality in the lead series with a sulfamide group resulted in improved physicochemical properties generating analogs with enhanced inhibition in cell-based and whole blood assays.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-hydroxy-5,8,11,13-eicosatetraenoi...,
http://linkedlifedata.com/resource/pubmed/chemical/Amides,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonate 15-Lipoxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyeicosatetraenoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/pyrazole
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AhmadSaleemS,
pubmed-author:ChenXingX,
pubmed-author:CombsDonald WDW,
pubmed-author:HarperTimothy WTW,
pubmed-author:LangevineCharlesC,
pubmed-author:LiuWenW,
pubmed-author:MadsenCort SCS,
pubmed-author:NguKhehyongK,
pubmed-author:RoblJeffrey AJA,
pubmed-author:WeinsteinDavid SDS,
pubmed-author:ZhuangShaobinS
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4141-5
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pubmed:meshHeading |
pubmed-meshheading:21696952-Amides,
pubmed-meshheading:21696952-Animals,
pubmed-meshheading:21696952-Arachidonate 15-Lipoxygenase,
pubmed-meshheading:21696952-CHO Cells,
pubmed-meshheading:21696952-Cricetinae,
pubmed-meshheading:21696952-Cricetulus,
pubmed-meshheading:21696952-Humans,
pubmed-meshheading:21696952-Hydroxyeicosatetraenoic Acids,
pubmed-meshheading:21696952-Lipoxygenase Inhibitors,
pubmed-meshheading:21696952-Pyrazoles,
pubmed-meshheading:21696952-Rabbits,
pubmed-meshheading:21696952-Structure-Activity Relationship,
pubmed-meshheading:21696952-Sulfonamides
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pubmed:year |
2011
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pubmed:articleTitle |
Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.
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pubmed:affiliation |
Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543, USA. khehyong.ngu@bms.com
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pubmed:publicationType |
Journal Article
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