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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0025260,
umls-concept:C0030956,
umls-concept:C0034789,
umls-concept:C0039194,
umls-concept:C0205147,
umls-concept:C0205369,
umls-concept:C0282491,
umls-concept:C0439682,
umls-concept:C0443286,
umls-concept:C1550015,
umls-concept:C1609614
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pubmed:issue |
1
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pubmed:dateCreated |
2011-6-21
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pubmed:abstractText |
A fundamental problem in immunoregulation is how CD4(+) T cells react to immunogenic peptides derived from the V region of the BCR that are created by somatic mechanisms, presented in MHC II, and amplified to abundance by B cell clonal expansion during immunity. BCR neo Ags open a potentially dangerous avenue of T cell help in violation of the principle of linked Ag recognition. To analyze this issue, we developed a murine adoptive transfer model using paired donor B cells and CD4 T cells specific for a BCR-derived peptide. BCR peptide-specific T cells aborted ongoing germinal center reactions and impeded the secondary immune response. Instead, they induced the B cells to differentiate into short-lived extrafollicular plasmablasts that secreted modest quantities of Ig. These results uncover an immunoregulatory process that restricts the memory pathway to B cells that communicate with CD4 T cells via exogenous foreign Ag.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1550-6606
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
212-21
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21622866-Adoptive Transfer,
pubmed-meshheading:21622866-Amino Acid Sequence,
pubmed-meshheading:21622866-Animals,
pubmed-meshheading:21622866-Antigen Presentation,
pubmed-meshheading:21622866-B-Lymphocyte Subsets,
pubmed-meshheading:21622866-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21622866-Cell Communication,
pubmed-meshheading:21622866-Epitopes, B-Lymphocyte,
pubmed-meshheading:21622866-Female,
pubmed-meshheading:21622866-Germinal Center,
pubmed-meshheading:21622866-Growth Inhibitors,
pubmed-meshheading:21622866-Immunoglobulin Variable Region,
pubmed-meshheading:21622866-Immunoglobulin kappa-Chains,
pubmed-meshheading:21622866-Immunologic Memory,
pubmed-meshheading:21622866-Mice,
pubmed-meshheading:21622866-Mice, Inbred A,
pubmed-meshheading:21622866-Mice, Knockout,
pubmed-meshheading:21622866-Mice, Transgenic,
pubmed-meshheading:21622866-Molecular Sequence Data,
pubmed-meshheading:21622866-Peptides,
pubmed-meshheading:21622866-Plasma Cells,
pubmed-meshheading:21622866-Receptors, Antigen, B-Cell
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pubmed:year |
2011
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pubmed:articleTitle |
Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide.
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pubmed:affiliation |
Integrated Department of Immunology, National Jewish Health and University of Colorado Denver, School of Medicine, Denver, CO 80206, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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