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pubmed:abstractText |
Increased expression of FGFR-4 and its ligands have been linked to lethal prostate cancer (PCa). Furthermore, a germ line polymorphism in the FGFR-4 gene, resulting in arginine at codon 388 (Arg³??) instead of glycine (Gly³??), is associated with aggressive disease. The FGFR-4 Arg³?? variant results in increased receptor stability, sustained receptor activation, and increased motility and invasion compared with Gly³??. However, the impact of sustained signaling on cellular signal transduction pathways is unknown.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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