Source:http://linkedlifedata.com/resource/pubmed/id/21606249
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2011-6-21
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pubmed:abstractText |
IL-17 and IL-23 are known to be absolutely central to psoriasis pathogenesis because drugs targeting either cytokine are highly effective treatments for this disease. The efficacy of these drugs has been attributed to blocking the function of IL-17-producing T cells and their IL-23-induced expansion. However, we demonstrate that mast cells and neutrophils, not T cells, are the predominant cell types that contain IL-17 in human skin. IL-17(+) mast cells and neutrophils are found at higher densities than IL-17(+) T cells in psoriasis lesions and frequently release IL-17 in the process of forming specialized structures called extracellular traps. Furthermore, we find that IL-23 and IL-1? can induce mast cell extracellular trap formation and degranulation of human mast cells. Release of IL-17 from innate immune cells may be central to the pathogenesis of psoriasis, representing a fundamental mechanism by which the IL-23-IL-17 axis mediates host defense and autoimmunity.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1550-6606
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pubmed:author |
pubmed-author:BruceAllen TAT,
pubmed-author:KaplanMariana JMJ,
pubmed-author:KhandpurRitikaR,
pubmed-author:LinAndrew MAM,
pubmed-author:RiblettMaryBethM,
pubmed-author:RubinCory JCJ,
pubmed-author:ShahParthP,
pubmed-author:VillanuevaEneida CEC,
pubmed-author:WangJennifer YJY,
pubmed-author:YalavarthiSrilakshmiS
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
490-500
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pubmed:dateRevised |
2011-9-2
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pubmed:meshHeading |
pubmed-meshheading:21606249-Chymases,
pubmed-meshheading:21606249-Extracellular Space,
pubmed-meshheading:21606249-Humans,
pubmed-meshheading:21606249-Immunity, Innate,
pubmed-meshheading:21606249-Interleukin-17,
pubmed-meshheading:21606249-Leukocyte Count,
pubmed-meshheading:21606249-Mast Cells,
pubmed-meshheading:21606249-Neutrophils,
pubmed-meshheading:21606249-Psoriasis,
pubmed-meshheading:21606249-Skin,
pubmed-meshheading:21606249-T-Lymphocyte Subsets,
pubmed-meshheading:21606249-Tryptases
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pubmed:year |
2011
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pubmed:articleTitle |
Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis.
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pubmed:affiliation |
Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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