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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1990-6-21
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pubmed:abstractText |
Transcriptional regulators containing a "leucine zipper" and a flanking basic domain belong to a recently identified class of DNA-binding proteins. We have mapped the essential DNA contacts of one member of this group, the eukaryotic transcription factor C/EBP. Methylation and ethylation interference experiments detected major groove contacts over a full turn of the DNA helix on both an asymmetric and a symmetric C/EBP binding site. The contacts essential for C/EBP binding have two-fold symmetry yet differ significantly from the contacts of other dimeric DNA-binding proteins, including those bearing helix-turn-helix motifs and the type I restriction endonuclease EcoRI.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-1062791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-164896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-2494700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-2494701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-2503872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-2530632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-2601714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-2673023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-2683088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-2824279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-2850264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-2911757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-2974179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-3004739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-3024321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-3187530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-3289117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-3315856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-3532321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-6273420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-6275366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2160081-6987648
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3992-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2160081-Alkylation,
pubmed-meshheading:2160081-Base Sequence,
pubmed-meshheading:2160081-Binding Sites,
pubmed-meshheading:2160081-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:2160081-DNA, Viral,
pubmed-meshheading:2160081-DNA-Binding Proteins,
pubmed-meshheading:2160081-Ethylnitrosourea,
pubmed-meshheading:2160081-Models, Molecular,
pubmed-meshheading:2160081-Molecular Sequence Data,
pubmed-meshheading:2160081-Nuclear Proteins,
pubmed-meshheading:2160081-Nucleic Acid Conformation,
pubmed-meshheading:2160081-Promoter Regions, Genetic,
pubmed-meshheading:2160081-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:2160081-Restriction Mapping,
pubmed-meshheading:2160081-Sarcoma Viruses, Murine,
pubmed-meshheading:2160081-Transcription Factors
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pubmed:year |
1990
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pubmed:articleTitle |
Alkylation interference identifies essential DNA contacts for sequence-specific binding of the eukaryotic transcription factor C/EBP.
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pubmed:affiliation |
Department of Cellular, Viral and Molecular Biology, University of Utah School of Medicine, Salt Lake City 84132.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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