Source:http://linkedlifedata.com/resource/pubmed/id/21598141
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2011-5-20
|
| pubmed:abstractText |
A simple, new method permitting the simultaneous determination and confirmation of trace residues of 24 different growth promoters and metabolites using liquid chromatography-mass spectrometry was developed and validated. The compounds were extracted from bovine tissue using acetonitrile; sodium sulphate was also added at this stage to aid with purification. The resulting mixture was then evaporated to approximately 1 ml and subsequently centrifuged at high speed and an aliquot injected onto the LC-MS/MS system. The calculated CC? values ranged between 0.11 and 0.46 µg kg(-1); calculated CC? were in the range 0.19-0.79 µg kg(-1). Accuracy, measurement of uncertainty, repeatability and linearity were also determined for each analyte. The analytical method was applied to a number of bovine tissue samples imported into Ireland from third countries. Levels of progesterone were found in a number of samples at concentrations ranging between 0.28 and 30.30 µg kg(-1). Levels of alpha- and beta-testosterone were also found in a number of samples at concentrations ranging between 0.22 and 8.63 µg kg(-1) and between 0.16 and 2.08 µg kg(-1) respectively.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anabolic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Androgens,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Progestins,
http://linkedlifedata.com/resource/pubmed/chemical/Veterinary Drugs
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1944-0057
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
597-607
|
| pubmed:meshHeading |
pubmed-meshheading:21598141-Anabolic Agents,
pubmed-meshheading:21598141-Androgens,
pubmed-meshheading:21598141-Animals,
pubmed-meshheading:21598141-Cattle,
pubmed-meshheading:21598141-Chromatography, High Pressure Liquid,
pubmed-meshheading:21598141-Drug Residues,
pubmed-meshheading:21598141-Estrogens,
pubmed-meshheading:21598141-European Union,
pubmed-meshheading:21598141-Food Inspection,
pubmed-meshheading:21598141-Humans,
pubmed-meshheading:21598141-Ireland,
pubmed-meshheading:21598141-Limit of Detection,
pubmed-meshheading:21598141-Meat,
pubmed-meshheading:21598141-Muscles,
pubmed-meshheading:21598141-Progestins,
pubmed-meshheading:21598141-Reproducibility of Results,
pubmed-meshheading:21598141-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:21598141-Statistics as Topic,
pubmed-meshheading:21598141-Tandem Mass Spectrometry,
pubmed-meshheading:21598141-Veterinary Drugs
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Surveillance study of a number of synthetic and natural growth promoters in bovine muscle samples using liquid chromatography-tandem mass spectrometry.
|
| pubmed:affiliation |
The State Laboratory, Backweston, Celbridge Co., Kildare, Ireland. edward.malone@statelab.ie
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Validation Studies
|