Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4954
pubmed:dateCreated
1990-5-25
pubmed:databankReference
pubmed:abstractText
The gene encoding the 49-kilodalton protein that undergoes light-induced phosphorylation in the Drosophila photoreceptor has been isolated and characterized. The encoded protein has 401 amino acid residues and a molecular mass of 44,972 daltons, and it shares approximately 42 percent amino acid sequence identity with arrestin (S-antigen), which has been proposed to quench the light-induced cascade of guanosine 3',5'-monophosphate hydrolysis in vertebrate photoreceptors. Unlike the 49-kilodalton protein, however, arrestin, which appears to bind to phosphorylated rhodopsin, has not itself been reported to undergo phosphorylation. In vitro, Ca2+ was the only agent found that would stimulate the phosphorylation of the 49-kilodalton protein. The phosphorylation of this arrestin-like protein in vivo may therefore be triggered by a Ca2+ signal that is likely to be regulated by light-activated phosphoinositide-specific phospholipase C.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
248
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
483-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:2158671-Amino Acid Sequence, pubmed-meshheading:2158671-Animals, pubmed-meshheading:2158671-Antigens, pubmed-meshheading:2158671-Arrestin, pubmed-meshheading:2158671-Binding Sites, pubmed-meshheading:2158671-Calcium, pubmed-meshheading:2158671-Cloning, Molecular, pubmed-meshheading:2158671-Cyclic GMP, pubmed-meshheading:2158671-DNA, pubmed-meshheading:2158671-Drosophila melanogaster, pubmed-meshheading:2158671-Enzyme Activation, pubmed-meshheading:2158671-Eye Proteins, pubmed-meshheading:2158671-Isoelectric Point, pubmed-meshheading:2158671-Molecular Sequence Data, pubmed-meshheading:2158671-Molecular Weight, pubmed-meshheading:2158671-Mutation, pubmed-meshheading:2158671-Phosphatidylinositol Diacylglycerol-Lyase, pubmed-meshheading:2158671-Phosphoproteins, pubmed-meshheading:2158671-Phosphoric Diester Hydrolases, pubmed-meshheading:2158671-Phosphorylation, pubmed-meshheading:2158671-Photoreceptor Cells, pubmed-meshheading:2158671-Protein Biosynthesis, pubmed-meshheading:2158671-Restriction Mapping, pubmed-meshheading:2158671-Sequence Homology, Nucleic Acid
pubmed:year
1990
pubmed:articleTitle
A 49-kilodalton phosphoprotein in the Drosophila photoreceptor is an arrestin homolog.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't