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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2011-7-26
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pubmed:abstractText |
RPE65 gene knockout (Rpe65?/?) mice showed abolished isomerohydrolase activity in the visual cycle and were considered a model for vitamin A deficiency in the retina. The purpose of this study was to compare the retinal phenotypes between vitamin A-deficient (VAD) mice and Rpe65?/? mice under normal diet.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1552-5783
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5507-14
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pubmed:dateRevised |
2011-9-30
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pubmed:meshHeading |
pubmed-meshheading:21551411-Acyltransferases,
pubmed-meshheading:21551411-Animals,
pubmed-meshheading:21551411-Blotting, Western,
pubmed-meshheading:21551411-Carrier Proteins,
pubmed-meshheading:21551411-Cell Count,
pubmed-meshheading:21551411-Chromatography, High Pressure Liquid,
pubmed-meshheading:21551411-Eye Proteins,
pubmed-meshheading:21551411-Gene Expression,
pubmed-meshheading:21551411-Injections, Intraperitoneal,
pubmed-meshheading:21551411-Mice,
pubmed-meshheading:21551411-Mice, Knockout,
pubmed-meshheading:21551411-Microscopy, Electron, Scanning,
pubmed-meshheading:21551411-Opsins,
pubmed-meshheading:21551411-Phenotype,
pubmed-meshheading:21551411-Photoreceptor Cells, Vertebrate,
pubmed-meshheading:21551411-Retinal Degeneration,
pubmed-meshheading:21551411-Retinal Photoreceptor Cell Outer Segment,
pubmed-meshheading:21551411-Retinal Pigment Epithelium,
pubmed-meshheading:21551411-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21551411-Tretinoin,
pubmed-meshheading:21551411-Vitamin A,
pubmed-meshheading:21551411-Vitamin A Deficiency,
pubmed-meshheading:21551411-cis-trans-Isomerases
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pubmed:year |
2011
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pubmed:articleTitle |
Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice.
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pubmed:affiliation |
Department of Physiology, Department of Medicine and Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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