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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-5-2
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pubmed:abstractText |
Schistosomal parasites can establish parasitization in a human host for decades; evasion of host immunorecognition including surface masking by acquisition of host serum components is one of the strategies explored by the parasites. Parasite molecules anchored on the membrane are the main elements in the interaction. Sjc23, a member of the tetraspanin (TSP) family of Schistosoma japonicum, was previously found to be highly immunogenic and regarded as a vaccine candidate against schistosomiasis. However, studies indicated that immunization with Sjc23 generated rapid antibody responses which were less protective than that with other antigens. The biological function of this membrane-anchored molecule has not been defined after decades of vaccination studies.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21533061-10417672,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e19112
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pubmed:meshHeading |
pubmed-meshheading:21533061-Amino Acid Sequence,
pubmed-meshheading:21533061-Animals,
pubmed-meshheading:21533061-Cloning, Molecular,
pubmed-meshheading:21533061-Humans,
pubmed-meshheading:21533061-Immunoglobulin G,
pubmed-meshheading:21533061-Membrane Proteins,
pubmed-meshheading:21533061-Models, Molecular,
pubmed-meshheading:21533061-Molecular Sequence Data,
pubmed-meshheading:21533061-Protein Binding,
pubmed-meshheading:21533061-Protein Conformation,
pubmed-meshheading:21533061-Recombinant Proteins,
pubmed-meshheading:21533061-Schistosoma japonicum
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pubmed:year |
2011
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pubmed:articleTitle |
Mapping the binding between the tetraspanin molecule (Sjc23) of Schistosoma japonicum and human non-immune IgG.
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pubmed:affiliation |
Key Laboratory of Zoonosis, The Ministry of Education, Jilin University, Changchun, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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