Linked Life Data

2151464

Source:http://linkedlifedata.com/resource/pubmed/id/2151464

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-7-23
pubmed:abstractText
The effects of agonist concentration, transmembrane voltage and calcium on the glycine-independent desensitization of N-methyl-D-aspartate receptors were examined in voltage-clamped postnatal rat hippocampal neurons. In the presence of 1 micron glycine and 1 mM calcium, both the time-course and degree of N-methyl-D-aspartate desensitization were dependent on agonist concentration. Transmembrane voltage influenced both the rate and degree of desensitization with a more rapid rate and greater degree at negative holding potentials. Both the time-course and the degree of desensitization were influenced by extracellular calcium in a dose-dependent manner. N-Methyl-D-aspartate desensitization is not augmented by activation of voltage-gated calcium currents and is more pronounced in the presence of intracellular calcium chelators, suggesting that the site of action of calcium in promoting desensitization is extracellular. Although a physiological role for N-methyl-D-aspartate desensitization has not been demonstrated, the process is observed over a range of agonist concentrations, is prominent near resting membrane potential and is regulated by physiologic concentrations of calcium. Thus desensitization could be an important neuroprotective mechanism during periods of prolonged glutamate exposure.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
787-97
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
The effect of agonist concentration, membrane voltage and calcium on N-methyl-D-aspartate receptor desensitization.
pubmed:affiliation
Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't