Linked Life Data

21491143

Source:http://linkedlifedata.com/resource/pubmed/id/21491143

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-5-19
pubmed:abstractText
HIV-1 clades (subtypes) differentially contribute to the neuropathogenesis of HIV-associated dementia (HAD) in neuroAIDS. HIV-1 envelop protein, gp120, plays a major role in neuronal function. It is not well understood how these HIV-1 clades exert these neuropathogenic differences. The N-methyl-D: -aspartate (NMDA) receptor-reduced glutamine synthesis could lead to secretion of neurotoxins such as arachidonic acid (AA) which plays a significant role in the neuropathogenic mechanisms in neuroAIDS. We hypothesize that clade B and C gp120 proteins exert differential effects on human primary astrocytes by production of the neurotoxin arachidonic acid. Our results indicate that clade B gp120 significantly downregulated NMDA receptor gene and protein expression, and level of glutamine while increasing expression of prostaglandin E2 (PGE(2)) and thromboxane A2 receptor (TBXA(2) R) compared to HIV-1 clade C gp120 protein. Thus, our studies for the first time demonstrate that HIV-1 clade B-gp120 protein appears to induce higher levels of expression of the neuropathogenic molecule cyclooxygenase-2 (COX-2)-mediated arachidonic acid by-products, PGE(2), and TBXA(2) R compared to HIV-1 clade C gp120 protein. These studies suggest that HIV-1 clade B and C gp120 proteins may play a differential role in the neuropathogenesis of HAD in neuroAIDS.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1538-2443
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
230-8
pubmed:meshHeading
pubmed-meshheading:21491143-AIDS Dementia Complex, pubmed-meshheading:21491143-Arachidonic Acid, pubmed-meshheading:21491143-Astrocytes, pubmed-meshheading:21491143-Cell Culture Techniques, pubmed-meshheading:21491143-Cells, Cultured, pubmed-meshheading:21491143-Cyclooxygenase 2, pubmed-meshheading:21491143-Dinoprostone, pubmed-meshheading:21491143-Down-Regulation, pubmed-meshheading:21491143-Glutamine, pubmed-meshheading:21491143-HIV Envelope Protein gp120, pubmed-meshheading:21491143-HIV Infections, pubmed-meshheading:21491143-HIV-1, pubmed-meshheading:21491143-Humans, pubmed-meshheading:21491143-Neurotoxins, pubmed-meshheading:21491143-Protein Isoforms, pubmed-meshheading:21491143-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:21491143-Receptors, Thromboxane A2, Prostaglandin H2, pubmed-meshheading:21491143-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:21491143-Up-Regulation
pubmed:year
2011
pubmed:articleTitle
Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS.
pubmed:affiliation
Department of Immunology, Institute of NeuroImmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, 11200 S.W. 8th Street, HLS-1 #418A, Miami, FL 33199, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural