rdf:type |
|
lifeskim:mentions |
umls-concept:C0018549,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0022614,
umls-concept:C0332453,
umls-concept:C0521390,
umls-concept:C0524637,
umls-concept:C0596902,
umls-concept:C1314939,
umls-concept:C1621749,
umls-concept:C1710236
|
pubmed:issue |
1
|
pubmed:dateCreated |
1990-9-20
|
pubmed:abstractText |
The effects of halothane and ketamine on (1) serotonin (5-hydroxytryptamine; 5-HT) uptake and (2) paroxetine binding to the 5-HT transporter in neuronal membranes were determined in rat brain. Both anesthetics inhibited the uptake of [3H]5-HT by synaptosomes, but only ketamine affected binding of [3H]paroxetine to the 5-HT transporter. Saturation analysis indicated that ketamine inhibition of [3H]paroxetine binding was competitive (Ki = 18.8 microM). These results indicate that halothane and ketamine inhibit 5-HT transport by different mechanisms.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0304-3940
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
20
|
pubmed:volume |
112
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
99-103
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2143567-Anesthetics,
pubmed-meshheading:2143567-Animals,
pubmed-meshheading:2143567-Brain,
pubmed-meshheading:2143567-Halothane,
pubmed-meshheading:2143567-Ketamine,
pubmed-meshheading:2143567-Male,
pubmed-meshheading:2143567-Neurotransmitter Uptake Inhibitors,
pubmed-meshheading:2143567-Paroxetine,
pubmed-meshheading:2143567-Piperidines,
pubmed-meshheading:2143567-Rats,
pubmed-meshheading:2143567-Rats, Inbred Strains,
pubmed-meshheading:2143567-Receptors, Serotonin,
pubmed-meshheading:2143567-Serotonin,
pubmed-meshheading:2143567-Synaptosomes
|
pubmed:year |
1990
|
pubmed:articleTitle |
Inhibition of neuronal 5-HT uptake by ketamine, but not halothane, involves disruption of substrate recognition by the transporter.
|
pubmed:affiliation |
Department of Anesthesiology, Medical College of Georgia, Augusta 30912.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|